Players control Spider-Man as he battles through various levels set to popular rock songs. The gameplay involves pressing buttons in time with the music to perform moves such as dodging attacks and performing combos. The game features a dynamic stage where players can interact with the environment, using items like webs and energy blasts to take down enemies.
One of the unique features of Guitar Hero Live Dongle is its guitar controller, which allows players to shred along with their favorite songs. The game also includes online multiplayer mode, allowing players to compete against each other in song-based challenges.