Bionic Commando follows the story of soldier Rad Spencer as he navigates through treacherous terrain with his trusty bionic arm. His mission is to find Super Joe, stop the Doraize army's plans, and thwart the schemes of Weisman and his Albatross project.
The gameplay in Bionic Commando for GameBoy involves a mix of action and adventure elements. Players control Rad Spencer as he climbs through levels, latches onto objects with his bionic arm, and fights against enemies. The game features neutral zones, generator bosses, and bullet collection to increase life bars, as well as communication rooms and upgrades to enhance gameplay.