Gameplay involves directing the slave Mudokons to their freedom using limited commands, such as "Hello", "Follow me", "Wait" and "Work". As players progress through levels, they must use these commands in creative ways to overcome obstacles and reach the end of each level. The game features an easy mode and a normal mode, allowing players to choose their level of difficulty.
One notable feature of Oddworld Adventures 2 is its use of passwords to save games, as well as infinite lives, which gives players the freedom to experiment with different approaches to completing levels.