Tweety's High-Flying Adventure is a platformer based on the direct-to-video animated movie of the same name. Granny sends off Tweety on a world trip to gather paw imprints of 80 cats in order to win a bet. There are overall 40 levels with ten scenarios, i.e. two cats per level. The levels themselves are relatively open and have to be explored in order to find the cats, especially by using Tweety's flutter ability. The player has to tap a button rapidly in order to keep him in the air longer.
The gameplay is action-packed with items found in the levels, such as banana peels or acorns, that must be used to overwhelm the cats and get access to their paws. However, Tweety also faces other enemies that take away parts of his life energy when touched. In addition, there is a two-player mode where players compete to collect as many paw imprints as possible within a limited time.