Time Killers is a one-on-one versus beat-em-up with gameplay similar to Mortal Kombat and Street Fighter 2. You can attack with all body parts - the head, both arms and both legs. A damage system allows arms to be hacked off, but fighters can keep going with only legs and the head.
A special feature allows characters to perform a decapitation manoeuver called a 'death move', which instantly kills an opponent and ends the round. The game features cartoon-like over-the-top blood and gore violence.
There are eight selectable characters, each with unique weapons and attributes pertaining to their time period, such as Thugg, a caveman from 20,000 BC, Musashi, a samurai from Feudal Japan, Orion, an intergalactic bounty hunter.
In the single player game, you can face off against Death himself if you manage to defeat all standard opponents.