Ludia's 2010 version of Who Wants to be a Millionaire brings the current version of the game show to home consoles. Players try to answer 15 multiple-choice questions of increasing difficulty, with the dollar value for each question increasing all the way up to one million dollars. If they player is stumped by a question, they may narrow their choices down by using up one of three lifelines - Ask the Audience, Double Dip, and Phone a Friend. Players can also choose to walk away and retain their winnings.
The gameplay involves answering questions in single-player mode, where the player plays as a contestant on the show. In multiplayer mode, players compete against each other in a "Party Mode" for up to four players. The game features virtual friends/audience presenting lifeline answers and awarding outfits and achievements based on performance.
Players must create a game profile and select an avatar from Ludia's standard designs to progress through the game. The player's total lifetime winnings are tracked in this mode, aiming to beat previous performances or achieve the highest dollar score possible.