Dead to Rights is a 3rd-person shooter game where the player takes on the role of Jack Slate, a police officer in Grant City. On a routine call, he discovers the dead body of his father. As he tries to find the murderer, he is framed for another murder and becomes a fugitive. His run from the law will take him to various places, including strip joints, hotels, office complexes, and even prison as an inmate.
When playing as Jack, players can perform different moves, such as grabbing an enemy from behind and using them as a human shield, or tossing a fire extinguisher and shooting it, causing a huge explosion. If Jack doesn't have his gun drawn, he can disarm an enemy, which causes him to steal their gun and then perform a finishing move like a neck breaker. Initially, only a few disarm moves are available, but more can be unlocked as the game progresses.
Players will also get to control Jack's best friend and partner, Shadow the K-9 dog. This allows enemies to be killed from a distance, and Shadow will fetch their guns and bring them to Jack.
The game features "adrenaline combat", similar to "Bullet Time" from Max Payne. Jack will perform slow-motion dives and spins, giving him an advantage as long as his adrenaline meter holds out.