Syndicate is set in a dystopian future where two rival corporations, Eurocorp Syndicate and Church of the New Epoch, engage in a battle for global supremacy. You play as the leader of either corporation, tasked with completing 60 violent missions across 30 cities worldwide.
Gameplay involves selecting a squad of four operatives and navigating through 3D city views, taking control of your team's movements and executing strategic actions on the fly. The game features new weapons, including nuclear grenades and psycho gas, as well as advanced transportation systems such as tubes and Antigrav vehicles. For multiplayer enthusiasts, online battles can be waged against other players over modem or network connections.