The story of Mass Destruction takes place in a post-apocalyptic world, where players must navigate through various environments as their one-man tank. The game features a wide range of terrain, from snowy arctic landscapes to hot desert dunes and urban cities, each with its unique challenges.
The gameplay revolves around blowing up enemy targets using the available arsenal of weapons. Each weapon has its strengths and weaknesses, making it essential for players to use the right tool for the job. From taking out helicopters with guided missiles to crushing infantry men beneath the tank's tracks, players must adapt their strategy to overcome the varied threats.