King of the Monsters 2 is similar to its predecessor. Choose from three monsters which include a large lizard, a large robotic ape, and a huge mutant human. Then walk through each city, making sure to destroy everything in site, including planes, buildings, and other creatures. When smashed, some buildings reveal power-ups that make your character more powerful. At the end of each city, you go head-to-head with the boss creature. There are small stages in between where you fight a second monster for bonus points, or you fall from the sky and land underwater where you try to collect points and power-ups while falling.
The gameplay is fast-paced and action-packed. You control your chosen monster as it moves through each city, fighting enemies and destroying objects to earn points. The monsters' powers can be upgraded with items found in buildings, allowing for more powerful attacks and increased health. Beating the boss creature at the end of each city rewards you with bonus points and power-ups.