In the New Correct Dimension, the star ship Yamato and Crossbone Vanguard embark on a desperate quest to reach the distant Iscandar star system to save an Earth dying from the Gamillas' Empire's planet killer weapon. In AD Dimension Might Senpuuji, the richest boy fights against criminals in Nouvelle Tokyo, while the girls of Arzenal island protect the world from dragons in order to pay for their continued existence. In the Universal Century Dimension, a broken world ravaged by endless war and ecological disaster attempts to heal as Mithril investigates Out Of Place technology. Super Robot Wars V is a standalone title marking the 25th anniversary of the Super Robot Wars franchise. This entry also marks the first appearance of Space Battleship Yamato, which is notable for not having any robots. The player selects their point-of-view character, either Souji Murakumo or Chitose Kisaragi, who can be renamed and has different reactions during cutscenes and missions. SRW V follows a similar game flow to past titles: Base mode, Adventure mode, Scenario mode, and then back again. In Adventure mode, the player watches the storyline play out, occasionally making decisions on which route to follow. In Scenario mode, the player deploys their forces to defeat opponents or achieve specific objectives.
Pilots level up with experience from enemy defeats, gaining stats and learning new Spirits that can temporarily boost abilities. Defeating opponents awards Tactical Points, which can be used to buy additional ranks of stat boosting Skill Programs. Pilots do not naturally learn any Skill Programs with levels, but Tactical Points belong to a single pool instead of being awarded per-pilot. SRW V introduces new features such as the ability to use any Spirit ability at any time, including during the enemy's turn. Some Skill Programs also allow units to join in with nearby attacks or leap to the defense of an ally. Completing optional objectives rewards SR points and Money, but playing on Beginner mode removes these bonuses.
SRW V features a sound edit feature allowing players to select any theme song for any unit in their force, including individual songs per attack. MP3s can be imported from memory cards or external drives, enabling any unit to have literally any music for its attacks.