As you play as Dr. Mario, your goal is to drop differently coloured pills into a bottle filled with viruses. Each pill comes in two halves, one side of each of three colours: red, blue or yellow. To remove a virus, align three pills of the same colour (or any combination of four) and it will be cleared from the bottle along with the aligned pills. The level is completed when there are no viruses left, and the game ends when pills reach the top and you can't drop more.
The Dr. Mario game includes three main modes: normal mode, a time trial, and a two-player battle mode to see who can remove the most viruses. This puzzle-style game is perfect for anyone looking for a challenge on their Game Boy console.