In an alternate version of Earth's history, a treaty was signed in the early 21st century, ending international conflicts. However, this era of peace is marred by continuous attacks from a terrorist group called "Heaven Smile", which consists of human mutants under the influence of a lethal virus. Targeted at the United Nations and the International Ethics Committee (IEC), the US government hires a group of assassins known as Killer7 , led by an elderly wheelchair-bound man named Harman Smith.
The group has seven different personalities, each with unique abilities, which can be switched during most parts of the game. These characters include Dan, Coyote, Con, Kaede, Mask, Kevin, and Garcian, the leader who possesses the ability to revive slain personalities. The gameplay combines shooting and puzzle-solving elements with light role-playing elements, allowing the player to switch between characters freely.
The game features 3D environments, but character navigation is restricted to pre-determined paths. Drawing out a weapon switches the view to a first-person perspective with free camera rotation, but no movement possible. The player must eliminate enemies quickly and efficiently using various combinations of characters and weapons to gather "blood", which can be turned into serum in special rooms and used to enhance abilities.
A significant portion of gameplay is dedicated to solving puzzles and gathering plot-related information by conversing with the game's exotic characters, while avoiding continuous attacks from Heaven Smile. This unique blend of gameplay mechanics offers a challenging experience for players.