The gameplay is similar to Nano Contra with a behind the back view where the player uses a variety of weapons including machine guns and rocket launchers and the Delta 6 Accelerator Suit that makes the player invulnerable for a short period of time. Using these weapons and accessories the player must fight his way through a horde of enemies including soldiers, tanks and jet fighters, along with the standard end of level bosses.
The player can choose from 12 different Joes, but only a certain set at the beginning and unlocking more for completing missions, each with their own weapon and strengths depending upon their rank ( Commandos are great at close range, Heavy Weapons are good at shooting from long distances while Soldiers are a mix of both), along with using various vehicles scattered throughout the stages. The game also features a two-player drop-in/drop-out co-op option that allows a friend to join a game at any time, however during gameplay without a human ally, the computer's A.I. will take over for the second on-screen soldier.