Men in Black the Series is a platform game that pits the player as either agent K or his rookie partner J against evil aliens and monstrous bosses threatening New York City. The mission takes the player through eight different levels, ranging from a hijacked aircraft to the Statue of Liberty.
The gameplay revolves around collecting four pairs of MIB sunglasses in each level before progressing further. The arsenal of weaponry includes standard-issue blasters, rocket launchers, and grenade launchers, as well as freeze rays, homing missiles, and the Noisy Cricket. Various items such as chemical protection suits, snowshoes, invisibility suits, and smart cards are also scattered throughout the levels to aid the player.