BloodRayne is a Gamecube action-adventure game where the half-vampire agent BloodRayne hunts down threats to humanity. Her mission takes her from swamps in Louisiana to fighting Nazi military members and awakened monsters worldwide. Rayne's primary weapons are her arm blades, which she will upgrade as the game progresses.
Gameplay involves battling monsters and humans alike using a combination of melee attacks, guns, and vampiric abilities. Rayne can hold multiple weapons at once, but discards them when they run out. Her enhanced strength allows her to destroy enemy gun emplacements and drain human blood for health regeneration. As the game progresses, Rayne's senses improve, enabling wall penetration, zooming, and slowing down time.