Mutants is a Commodore 64 action and adventure game where the player takes on the role of Bart Simpson, tasked with stopping the Space Mutants from invading Springfield.
The objective is to collect ingredients that the Space Mutants plan to use to build their machine. The player must navigate through five levels, collecting or disposing of purple objects, brown coins left behind by the aliens, and using X-ray Specs to uncover the true identity of the mutans. The player's progress will be aided by his family members if he can defeat a boss, such as Nelson or Sideshow Bob.
The game requires creative problem-solving, with options ranging from dyeing objects red to solving puzzles, like playing a trick on Moe to make him leave the bar. Bart also has coins that can be used to purchase items, activate devices, and overcome obstacles.