Duke Nukem 3D is an action-packed game where aliens have invaded futuristic Los Angeles, and it's up to Duke Nukem 3D to take them down. The game introduces a first-person perspective to the series, turning it into a full-fledged shooter with 2.5D graphics.
The gameplay is highly interactive, with Duke having access to a wide range of arsenal including pistols, pipe bombs, and various rocket launchers. He can also interact with objects in the environment, such as breaking glass or using light switches. The game features twenty-eight levels divided over three episodes, set in various locations like streets, churches, and space stations.
Enemies include aliens, mutated humans, and even police officers turned into "Pig Cops". Duke has access to various power-ups, such as medikits, steroids, night vision, protective boots, a hologram known as the "holoduke", and a jetpack. The gameplay is action-oriented, but also requires puzzle-solving to progress or access secret areas.
The game features network play through IPX protocol for deathmatch and cooperative games, allowing players to compete against each other in various modes.