Major League Baseball 2K6

The game has standard modes such as exhibition, season, and a new feature allowing players to take on the role of an international team in the World Baseball Classic. Players can also challenge umpires if they feel a call has been botched, which can affect the team's morale for better or worse.

There are online capabilities for each console version, including the ability to download a friend's profile using the V.I.P. system, which allows players to view their stats and results, giving them an upper hand in online matches.